A Pharmacological Investigation on CNS Activity of Methanolic Extract of Syzygium samarangense Leaves

Abstract

Syzygium samarangense (Family: Myrtaceae) has been widely used as a traditional medicine for the cure of diarrhea, amenorrhea, diabetes, stomatitis, and many other ailments in various countries. Multiple researches have been conducted to identify its various chemical constituents and also several pharmacological activities of the components. The current study was performed to evaluate the CNS effects of Methanolic extracts of the leaves of Syzygium samarangense in Swiss albino mice model. The leaves were powdered and then soaked in Methanol to prepare the extract. Two doses: 100 mg/kg and 200 mg/kg body weight were selected to test the activity by using the Open Field Test and Hole Board Experiment. In case of both the experiments, significant (p<0.001) decrease in locomotor activity in the mice model was observed in a dose-dependent manner when compared with the standard drug, Diazepam. Thus, it can be said that this plant can be a potential candidate for the development of Depressant drugs acting on the Central Nervous System (CNS) in near future.