Study of Pharmacological and toxicological Activities of Methanolic Extract of Grewia asiatica

Abstract

Purpose: The research work was carried out to determine the pharmacological activities of methanolic extract of Grewia asiatica Method: Methanolic leaf extract was administered orally to the animal model (Swiss albino) and the effects were determined by comparing with respect to control group which were treated with 5% CMC. For every experiment positive control was used. Different experiments were used to determine the pharmacological profile which was Collected from internationally published publications and journals. Result: The Laxative Effect was evaluated by Charcoal meal GI transit test where methanolic extract at dose of 800 mg/kg body weight increase the charcoal transit which compare with positive control. The CNS activity was evaluated by open field method and hole board test. In the open field method experiment the crude extract of Grewia asiatica. (200mg/kg, 400mg/kg & 800mg/kg) dose dependently reduces the number of peripheral locomotion, central locomotion and leaning in the open field test and. The reduction is significant (***p<0.001) when it is compared to the standard drug. The aim of the study was also to investigate the possible toxicity of the plant and especially to esta Grewia asiatica blish the safety of the methanolic extract of this plant by focusing on its acute and chronic toxicity in mice. For finding chronic toxicity several tests are done such as CBC (Cell Blood count) test, Hepatic enzyme test and histopathological Studies. All data were analyzed by using SPSS analytical method. Conclusion: After summarize all the results it can say that bark of Grewia asiatica may have several pharmacological activities but to prove the hypothesis it need further higher studies of Grewia asiatica