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Phytochemical & Pharmacological Investigations On Dichloromethane (Dcm) Fraction Of Ficus Hispida Leaf Extract

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dc.contributor.author Mitu, Mithila Habib
dc.date.accessioned 2018-03-12T11:35:13Z
dc.date.available 2018-03-12T11:35:13Z
dc.date.issued 12/17/2017
dc.identifier.uri http://dspace.ewubd.edu/handle/2525/2665
dc.description This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh. en_US
dc.description.abstract The study was designed for pharmacological investigation of dichloromethane (DCM) fraction of methanol extract of the leaves of Ficus hispida. The powdered leaves of Ficus hispida were extracted with methanol and then partitioned with n-hexane, dichloromethane and ethyl acetate consecutively. The DCM fraction remaining was investigated for total flavonoid content, total phenol content, brine shrimp lethality test. The fraction contained 139.167 mg AAE/gm of dried extract in total phenolic content assay and 35.3396mg quercetin/gm of dried extract in total flavaniod content assay. Screening for cytotoxic properties using brine shrimp lethality bioassay with tamoxifen (LC50 value of 0.78726 μg/ml) as positive control showed that the fraction have considerable cytotoxic potency exhibiting LC50 value 23988329194.9045 μg/ml. The DCM fraction showed weak cytotoxic activity, low antioxidant activity. Further investigations are needed for the proper identification and isolation of these bioactive compounds to produce safer drugs for treatment of harmful diseases. en_US
dc.language.iso en_US en_US
dc.publisher East West University en_US
dc.relation.ispartofseries ;PHA00715
dc.subject Ficus hispida, Brine shrimp lethality bio-assay, phenolic content, flavonoid content. en_US
dc.title Phytochemical & Pharmacological Investigations On Dichloromethane (Dcm) Fraction Of Ficus Hispida Leaf Extract en_US
dc.type Thesis en_US


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