Abstract:
Among the pathologic hypotheses of Alzheimer’s disease (AD), cholinergic deficit and
oxidative stress have been implicated as two major hallmarks. Therefore, inhibition of
cholinesterase and oxidation are the two promising strategies in the development of a drug for
AD. Pleurotus ostreatus fungi extract is used in this research to investigate its
anticholinesterase and antioxidant potentials. Anticholinesterase activity was measured by
modified Ellman’s method. Antioxidant potentials were evaluated by the assay of reducing
power, radical scavenging. The Methanolic extract showed strong antioxidant effect.
Additionally, the extract exhibited pronounced reducing capacity. The fungi extract found
moderate inhibitor of cholinesterase. The tested sample reflects potential antioxidative and
moderate anticholinesterase inhibitory effect which may warrant its effectiveness in the
treatment of AD.
Description:
This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh.
