Abstract:
Purpose: The purpose of this research work was to investigate the correlation between the
release profile and hardness of Salbutamol Sulphate tablets. Method: Thirty tablets of
Salbutamol Sulphate 4 were collected from the market and were characterized by
physical parameters like hardness, thickness, weight variation, friability and dissolution
studies. Salbutamol Sulphate release was investigated using the method inscribed in
Appendix XII B: Dissolution tests for tablets and capsules of British Pharmacopoeia.
Hardness of the withdrawn samples from the market was measured by Monsanto hardness
tester. Thickness of the samples was measured by Vernier Calipers. Dissolution of the taken
samples was investigated using dissolution tester (RC6, Vanguard Pharmaceuticals, USA) to
evaluate release kinetics. Result: Mean hardness value of the tablets was found to be
Sultolin 1O.OlN; VentoIin 12.71N; BrodiJ 14.72N and Salbutal 13.0SN. Mean thickness
value of Indapamide tablets was found to be - Salbutal 6.32 mm; Vento lin 8.42 mm; Sultolin
8.17 mm; and Brodil 9.77 mm. Percentage difference of the weight variation test ranged as -
Sultolin -1.68 to 1.83%; Vento lin to 3.27%; Brodil between -2.4 to 3.44%; and Salbutal
between -3.91 to 2.93%. Conclusion: The release pattern of Salbutamol tablet did not
completely fulfill its requirement to provide desired and optimum drug release. Best results
were obtained for Brodil of ACI Pharmaceuticals, as it showed a progressive increase in the
concentration and released the drug properly. Sultolin of Square Pharmaceuticals, showed
more or less acceptable increasing release profile. Salbutal of Sanofi Aventis and Vento lin of
GlaxoSmithKline showed less prominent characteristics of hardness and release profile
Description:
This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh.
