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Correlation Between Hardness and Release Profile of Salbutamol Sulphate Tablets

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dc.contributor.author Raihana, Shahreen
dc.date.accessioned 2023-07-31T03:38:25Z
dc.date.available 2023-07-31T03:38:25Z
dc.date.issued 2009-12-24
dc.identifier.uri http://dspace.ewubd.edu:8080/handle/123456789/4041
dc.description This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh. en_US
dc.description.abstract Purpose: The purpose of this research work was to investigate the correlation between the release profile and hardness of Salbutamol Sulphate tablets. Method: Thirty tablets of Salbutamol Sulphate 4 were collected from the market and were characterized by physical parameters like hardness, thickness, weight variation, friability and dissolution studies. Salbutamol Sulphate release was investigated using the method inscribed in Appendix XII B: Dissolution tests for tablets and capsules of British Pharmacopoeia. Hardness of the withdrawn samples from the market was measured by Monsanto hardness tester. Thickness of the samples was measured by Vernier Calipers. Dissolution of the taken samples was investigated using dissolution tester (RC6, Vanguard Pharmaceuticals, USA) to evaluate release kinetics. Result: Mean hardness value of the tablets was found to be Sultolin 1O.OlN; VentoIin 12.71N; BrodiJ 14.72N and Salbutal 13.0SN. Mean thickness value of Indapamide tablets was found to be - Salbutal 6.32 mm; Vento lin 8.42 mm; Sultolin 8.17 mm; and Brodil 9.77 mm. Percentage difference of the weight variation test ranged as - Sultolin -1.68 to 1.83%; Vento lin to 3.27%; Brodil between -2.4 to 3.44%; and Salbutal between -3.91 to 2.93%. Conclusion: The release pattern of Salbutamol tablet did not completely fulfill its requirement to provide desired and optimum drug release. Best results were obtained for Brodil of ACI Pharmaceuticals, as it showed a progressive increase in the concentration and released the drug properly. Sultolin of Square Pharmaceuticals, showed more or less acceptable increasing release profile. Salbutal of Sanofi Aventis and Vento lin of GlaxoSmithKline showed less prominent characteristics of hardness and release profile en_US
dc.language.iso en_US en_US
dc.publisher East West University en_US
dc.relation.ispartofseries ;PHA00019
dc.subject Salbutamol Sulphate Tablets, Hardness and Release Profile en_US
dc.title Correlation Between Hardness and Release Profile of Salbutamol Sulphate Tablets en_US
dc.type Thesis en_US


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