Abstract:
Purpose: The purpose of this research work was to investigate the release pattern of
Indapamide from Hypen SR matrix tablets. Method: Thirty tablets of Hypen SR were
collected from the market and were characterized by physical parameters like hardness,
thickness, weight variation and dissolution studies. Indapamide release was investigated
using the method inscribed in Appendix XlI B: Dissolution tests for tablets and capsules
of British Pharmacopoeia. Hardness of the withdrawn samples from the market was
measured by hardness tester (Veego, Germany). Thickness of the samples was measured
by Vernier Calipers. Dissolution of the taken samples was investigated using dissolution
tester (RC6, Vanguard Pharmaceuticals, USA) to evaluate release kinetics. Result: Mean
hardness value of Indapamide tablets was found to be 54.03 N. Mean thickness value of
Indapamide tablets was found to be 0.59 cm. Percentage difference of the weight
variation test ranges from -4.17 % to 3.39 %. Conclusion: The release pattern of Hypen
SR 1.5mg tablet did not fulfill its requirement to provide desired and optimum sustained
release of the drug with the increase of time.
Description:
This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh.
