An Investigation of an in Vitro Release Pattern of Indapamide from Hypen SR Matrix Tablets

Abstract

Purpose: The purpose of this research work was to investigate the release pattern of Indapamide from Hypen SR matrix tablets. Method: Thirty tablets of Hypen SR were collected from the market and were characterized by physical parameters like hardness, thickness, weight variation and dissolution studies. Indapamide release was investigated using the method inscribed in Appendix XlI B: Dissolution tests for tablets and capsules of British Pharmacopoeia. Hardness of the withdrawn samples from the market was measured by hardness tester (Veego, Germany). Thickness of the samples was measured by Vernier Calipers. Dissolution of the taken samples was investigated using dissolution tester (RC6, Vanguard Pharmaceuticals, USA) to evaluate release kinetics. Result: Mean hardness value of Indapamide tablets was found to be 54.03 N. Mean thickness value of Indapamide tablets was found to be 0.59 cm. Percentage difference of the weight variation test ranges from -4.17 % to 3.39 %. Conclusion: The release pattern of Hypen SR 1.5mg tablet did not fulfill its requirement to provide desired and optimum sustained release of the drug with the increase of time.