Pharmaceutical Equivalence Investigations of Different Brands of Naproxen Tablet

Abstract

The quality of pharmaceutical finished dosage forms is of major concern to the pharmaceutical industries. Tablet dosage form of any pharmaceutical company goes through many research studies and experiments to maintain the proper quality standards. The aim of this study was to investigate the quality of different brands of naproxen tablets which are manufactured in Bangladesh. Different physical parameters like hardness, thickness, friability as well as disintegration time, and dissolution rates were conducted to evaluate the quality of the tablets of different brands of naproxen. To assess its effectiveness potency test was conducted. The range of hardness test result of Naprosyn, Sonap, Naspro and Naid are respectively 7.75, 7.25, 4.0 and 5.83 kg. Among four brands two selected brands were shown more than the standard hardness value. The friability test results were all in range of the standard value. The thickness of Naprosyn, Sonap, Naspro and Naid are 4.1, 7.1, 6.0 and 5.32 mm. The disintegration test has mean time of Naprosyn, Naspro and Naid are 4.16,6.61 and 15.28 minute. The potency results were 95.62% , 56.1% , 102.62% and 74.46% whereas the standard contain 99.29 % potency. The average dissolution test results have values are 95.16% , 95.47% , 96.06% and 94.63%. The hardness test of half of the selected brands was more than the usual standards. The excess hardness can delay the tablet breakdown process in the biological system. The friability test results are all in range. A good quality product must be able to withstand the undesired pressure. To determine this, friability test is necessary. The thickness test of all the brands was complied with the standard values except sonap. The potency value of some brands of naproxen tablet showed some higher and lower than the standard value. These values can be a result of experimental error. The dissolution test results showed values in the range of standards except Sonap and Naspro which showed a lower then standard value. Quality of a product is the major issue for any pharmaceutical company. To ensure quality product a pharmaceutical industry follows the international standards.