Variation of Flow Property of different set of Formulas of excipients against various ratios of different Binders

Abstract

Flow property means the physical properties of moving ability of pharmaceutical powders. It is very much important in the pharmaceutical industry for the operations such as blending, tablet compression, capsule filling, transportation, and in scale-up operation. Our purpose is to isolate that ratio of pharmaceutical excipients in a mixture that will provide maximum flow property. Our proposed equations will be helpful for determining the flow property of new drug formulations. We had measured several parameters, such as, bulk density, tapped density, Carr’s index, Hausner ratio and angle of repose for different mixture of same pharmaceutical excipients but in different ratio, and were able to resolve an equation. We had done this for different mixtures of different excipients to determine different equations. We used several software, such as Microsoft excel, SPSS etc. to determine these equations. By evaluating the laboratory experimental data, we were able to determine several specific equations (y= mx + c) for particular mixtures of specific pharmaceutical excipients. My work was based on the variation in flowability of mixtures due to the presence of different amount of bingers. Flow property of pharmaceutical excipients for a new drug formulations can be predicted and measured by these equations.