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Determination of Flow Property of Different Groups of Excipients with Different Amounts of Disintegrants

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dc.contributor.author Mufti, Mynul Islam
dc.date.accessioned 2014-06-29T04:09:03Z
dc.date.available 2014-06-29T04:09:03Z
dc.date.issued 12/4/2013
dc.identifier.uri http://dspace.ewubd.edu/handle/2525/674
dc.description This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) of East West University, Dhaka, Bangladesh en_US
dc.description.abstract Powder flow characteristic is an important parameter during drug manufacturing process. The aim of this research work is determine the power flow characteristics of different excipients. Powder flow characteristic was determined using different parameter, for example, angle of repose, Carr’s index and Hausner ratio. At first, some excipients were selected to form a mixture and then three disintegrants, eg., starch, polyvinyl pyrrolidone, carboxymethyl cellulose and microcrystalline cellulose were added in different ratios. Finally values of angle of repose, Carr’s index and Hausner ratio of different ratios were determined. Variation in the values of angle of repose, Carr’s index and Hausner ratio were observed after addition of different amounts of disintegrants. It was observed that flow property was improved after addition of some excipients. This research work for the thesis project has shown the improvement in flow characteristic while using different amounts of disintegrants in a drug formulation. In addition the numerical data, the regression values and equations may further be used to predict the flow characteristics of these widely used excipients, and this will be beneficial for manufacturing new products or transforming the existing one in pharmaceutical industry. en_US
dc.language.iso en_US en_US
dc.publisher East West University en_US
dc.relation.ispartofseries ;PHA00329
dc.subject Powder flow property, Excipients en_US
dc.title Determination of Flow Property of Different Groups of Excipients with Different Amounts of Disintegrants en_US
dc.type Thesis en_US


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