Variation of Flow Property of Different Set of Formulas of Excipients Against Variable Ratio of Different Diluents

Abstract

This work was proposed to determine flow properties of different set of some important pharmaceutical excipients that are most commonly used for the directly compressible tablets and to search for some equations which can predict the flow property of any set of excipients with different ratio of diluents. Different parameters to determine flow property such as Compressibility index, Hausner ratio, and angle of repose were observed for them. Many unique formulas were equipped by choosing various excipients from different classes. Diluents were mixed with these prepared formulas in different specific and justified ratio. The prepared mixture in a constant weight (5g) was then examined for measuring flow property. The values of Carr’s index, Hausner ratio and angle of repose were plotted against the percentage ratios of diluents. The study showed a linear relationship with different ratios of mixture and flow property measuring parameters. From these graphs the straightline equation for each set of formula were obtained with regression value close to 1 which can be used to predict the flow property of these formula with different ratio of diluents. Moreover the most suitable ratio of specific diluents and a specific set of other excipients were proposed that showed better flow property.