Determination of photolytic degradation of Melixiol (Flupentixol-Melitracen) Combination Product

Abstract

The aim of this study is to identify the photolytic degradation of the Melixol,Square pharmaceutical, Bangladesh, combination product Flupentixol-Melitracin.Each tablet contains Flupentixol INN 0.5 mg(as di-hydrochloride) and Melitracen INN 10 mg (as hydrochloride). It is well known that light or other electromagnetic radiation can change the properties of some drug compounds. The most obvious way to identifying the responds is to measure the potency degradation of the drug, which I have conducted in my research project. Here the loss of potency is measured by UV-spectrometry. Beside the potency observation physical parameters were also determine to observed change of the physical characteristic like color, thickness, weight variation, hardness etc. of the tablets.At the end of the study , it was proved that Melixol drug is not photo stable and should have some protection in the final dosage form to save it from degradation.