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Formulation and Evaluation of Diclofenac 12H SR Matrix from Hydrophilic Polymer

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dc.contributor.author Fardous, Tamanna
dc.date.accessioned 2019-02-26T09:46:07Z
dc.date.available 2019-02-26T09:46:07Z
dc.date.issued 3/28/2010
dc.identifier.uri http://dspace.ewubd.edu/handle/2525/2951
dc.description This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh. en_US
dc.description.abstract The study was done to evaluate six fonnulations of Diclofenac Sodium SR 12H incorporated with two different polymers ( Methocel K 15 MCR & Methocel 1 00 LV CR). The polymers played an important role upon the % drug release. The fonnulations (F-l to F-6) polymer ratio was (1:5, 3:4, 2:5, 4:3, 3:3, 3:5). The fonnulations F-3 & F-6 fulfill the official requirements in 2 hour is simulated acidic (PH 1.3) and 8 hour in buffer (PH 6.8). Dissolution was done by USP reference dissolution apparatus .The physical evaluation such as bulk density, compressibility index, angle of repose, total porosity, hausner ratio, hardness & friability test, thickness, weight variation test was also done. In vitro drug release profile was extra cloated by drug release kinetics Zero order and First order equation. en_US
dc.language.iso en_US en_US
dc.publisher East West University en_US
dc.relation.ispartofseries ;PHA00034
dc.subject Diclofenac, Sustained release, Matrix tablets, Hydrophilic polymer, Methocel K 15 MCR, Methocel 1 00 LV CR, Direct compression. en_US
dc.title Formulation and Evaluation of Diclofenac 12H SR Matrix from Hydrophilic Polymer en_US
dc.type Thesis en_US


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