Abstract:
An experiment was conducted to determine the antinociceptive effect of methanolic extract of Aegle marmelos bark in swiss albino mice. The nociceptive effect was induced in test animals by administering 0.6% Acetic acid solution intraperitoneally. Control group received normal saline (10ml/kg i.p) and diclofenac (10mg/kg i.p) was used as a reference drug. The result has shown that oral administration of Aeg/e marvelous bark extract (250 mg/kg and 500 mg/kg) produced antinociception against acetic acid-induced writhing. The percent inhibition of writhing observed by the bark extract administered at a dose of 250 mg/kg was 73.89% (p=O.O); and that for the dose of 500 mg/kg was 97.34%(p=0.000008); the latter result was even higher than the data showed by the positive control diclofenac (88.49%). Therefore the present results suggest that methanolic extract of Aeg/e marmelos bark may play role in reducing pain or can that methanolic extract of Aeg/e marmelos bark may playa role in reducing
Description:
This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh.
