EWU Institutional Repository

Comparative Analysis of in Vitro Release Kinetics Among Sultolin®, Ventolin®, Brodil®, and Salbutal®

Show simple item record

dc.contributor.author Ireen, Kazi
dc.date.accessioned 2019-02-26T09:46:41Z
dc.date.available 2019-02-26T09:46:41Z
dc.date.issued 12/24/2009
dc.identifier.uri http://dspace.ewubd.edu/handle/2525/2960
dc.description This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh. en_US
dc.description.abstract Background: The purpose of this research work was to determine the in vitro release profile kinetics of four brands (Sultolin, Vento lin, Brodil and Salbutal) of salbutamol tablet of Bangladesh. Method: Ten tablets from each brand were taken to perform thickness test, weight variation test, friability test, and hardness test individually. Another two tablets from each brand were taken to do the dissolution test. Thickness tests were done using the Vernier Calipers. Weight variation tests were done using electronic weighing balance. Friability tests were done in the Roche Friabilator and hardness tests Monsanto Hardness Tester. The dissolution test was performed using dissolution tester (RC6, Vanguard Pharmaceuticals, USA). After dissolution test of the four brands absorbances were compared with the standard solution of crude salbutamol sulphate. Result: The average thickness of Sultolin, Ventolin, Brodil and Salbutal were found 8.l7mm, 8.42mm, 9.77mm and 6.32mm respectively. The % friability of Sultolin, V entolin , Brodil and Salbutal were 0.37, 0.17, -0.14, -0.10 respectively. The mean hardness values of Sultolin, Vento lin, Brodil and Salbutal were 10.007N, 11.64N, 14.72 ~ and 13.04N respectively. Average weights of Su1tolin, Ventolin, Brodil and Salbutal \!Jere found 0.17103gm, 0.20097 gm, 0.19688gm and 0.10086gm respectively. No brand met the absorbance of standard salbutamol sulphate. Conclusion: After conducting all the tests to determine various parameters, it has been found that, release profile kinetics of Sultolin, Ventolin, Brodil and Salbutal differed a lot from each other and also from the standard. en_US
dc.language.iso en_US en_US
dc.publisher East West University en_US
dc.relation.ispartofseries ;PHA00032
dc.subject Vitro Release Kinetics Among Sultolin, Ventolin, Brodil and Salbutal en_US
dc.title Comparative Analysis of in Vitro Release Kinetics Among Sultolin®, Ventolin®, Brodil®, and Salbutal® en_US
dc.type Thesis en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account