Abstract:
Background: Ibuprofen is widely used for treating fever in children. Like paracetamol,
aspirin, and physical methods (such as fanning), Ibuprofen aims to provide relief from
symptoms and prevent febrile convulsions. Objectives: To assess the effect of liquid
ibuprofen for remission of fever in hospitalized children aged less than 60 months.
Materials and methods: Twelve subjects aged less than 60 months admitted to the
Institute of Child Health and Shishu Sasthya Foundation Hospital (ICH&SSF) were
included in this study. The body temperature of the patients was recorded at different
time interval before and after administration of liquid Ibuprofen preparation. The patients
were given 10mg/kg dose of liquid Ibuprofen. Body temperature was recorded by
thermometer after 15, 30, 60, 90, 120, 150 and 180 minutes of the administration of
liquid Ibuprofen. Data analysis: Data were analyzed by using Paired sample T -test.
Result: After administration of liquid Ibuprofen the body temperature of the patients
starts to reduce from 1 ° 1. 92°F to 99.290F. It takes about 3 hours to reach the lowest body
temperature of 99.290F. In some cases the temperature increases slightly after 1 :30 to
2:00 hours of the administration of Ibuprofen, because the terminal half life of the drug is
1 to 2 hours. Conclusion: Liquid preparation of Ibuprofen has effect of lowering body
temperature of the febrile children.
Description:
This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh.
