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In Vitro Kinetic Studies of Combined Amlodipine (5mg) and Atenolol(50mg) Tablet Dosage Form: A Comparative Study with Similar Market Products Available in Bangladesh

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dc.contributor.author Rahman, Anusha
dc.date.accessioned 2019-02-26T09:47:13Z
dc.date.available 2019-02-26T09:47:13Z
dc.date.issued 2/10/2010
dc.identifier.uri http://dspace.ewubd.edu/handle/2525/2970
dc.description This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh. en_US
dc.description.abstract The objective of this study is to establish an immediate release Amlodipine (5mg) and Atenolol (50mg) tablet (a multilayer tablet) based upon the physical properlies of granules and prepared tablets. Multi-drug tablets of amlodipine besylate and atenolol were prepared as either mono-layer (mixed matrix) containing each drug in a separate layer by using similar excipients and processing. The combined dosage form is beneficial in the treatment of cardiovascular diseases such as hypertension, Angina pectoris, and Myocardial infarction. Before going to evaluate the o/o release of a drug, it is necessary to develop a suitable formulation first and then apply the correct tablet manufacturing process to obtain the required sample. In the designing of the tablet, the excipients and tablet manufacturing technique plays an important role. The sample is then compared with other market products currently available, in terms of their % dissolution rates. This study gives idea on how different excipients and manufacturing techniques can be used to formulate and hence develop a sample of a combined dosage form and compare its rates of dissolution with other market products. Accordingly we can get an idea of the performance of the developed tablet in relation with its competitors. en_US
dc.language.iso en_US en_US
dc.publisher East West University en_US
dc.relation.ispartofseries ;PHA00071
dc.subject Amlodipine (5mg) and Atenolol (50mg) tablet, excipients, %o dissolution rates, manufacturing technique, combined dosage form. en_US
dc.title In Vitro Kinetic Studies of Combined Amlodipine (5mg) and Atenolol(50mg) Tablet Dosage Form: A Comparative Study with Similar Market Products Available in Bangladesh en_US
dc.type Thesis en_US


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