Abstract:
The objective of this study is to develop a formulation for an immediate
release Amlodipine (Smg) and Atenolol (SOmg) tablet (a monolayer or mixed
matrix tablet) and then utilize the correct manufacturing method to bring out
the final sample. The combination therapy is useful for the effective treatment
of cardiovascular diseases such as hypertension, Angina pectoris, Myocardial
infarction. Multi-drug tablets of amlodipine besylate and atenolol were
prepared as mono-layer (mixed matrix) tablets containing each drug in a
separate layer by using various excipients and processing. After this is
complete it is necessary to evaluate the performance of the obtained sample
with its competitors that are currently available on the market. This has been
done by deducing the % dissolution rate of the sample and then comparing this
data with the % dissolution rates of its pharmaceutical competitors. We know
that when launching a product onto the market, a lot of research is essential in
order to determine whether it should or should not go into the market. This
research work is similar to that, although not as extensive and thorough, and
aims at determining whether the sample developed is comparable with its
existing pharmaceutical competitors.
Description:
This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh.
