Design and Formulation of In Vitro release of Combined Amlodipine (5mg) and Atenolol (50mg) Tablets and their Comparative Study with other Similar Market Products

Abstract

The objective of this study is to develop a formulation for an immediate release Amlodipine (Smg) and Atenolol (SOmg) tablet (a monolayer or mixed matrix tablet) and then utilize the correct manufacturing method to bring out the final sample. The combination therapy is useful for the effective treatment of cardiovascular diseases such as hypertension, Angina pectoris, Myocardial infarction. Multi-drug tablets of amlodipine besylate and atenolol were prepared as mono-layer (mixed matrix) tablets containing each drug in a separate layer by using various excipients and processing. After this is complete it is necessary to evaluate the performance of the obtained sample with its competitors that are currently available on the market. This has been done by deducing the % dissolution rate of the sample and then comparing this data with the % dissolution rates of its pharmaceutical competitors. We know that when launching a product onto the market, a lot of research is essential in order to determine whether it should or should not go into the market. This research work is similar to that, although not as extensive and thorough, and aims at determining whether the sample developed is comparable with its existing pharmaceutical competitors.