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Prospect of Compressed Pellets of Diclofenac and Rantidine as a Single Tablet Dosage Form

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dc.contributor.author Chaity, Nazia Akhter
dc.date.accessioned 2019-02-26T09:47:28Z
dc.date.available 2019-02-26T09:47:28Z
dc.date.issued 12/27/2009
dc.identifier.uri http://dspace.ewubd.edu/handle/2525/2976
dc.description This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh. en_US
dc.description.abstract Introduction:- Combination dosage forms are gammg approval in global markets in increasing numbers. Combining two or more drugs result in a product that is more effective than its separate components. Objective: - To investigate the combined effect of diclofenac and ranitidine together as enteric coated pellet form which is compressed into tablet formulation. Methods: -I this study an innovative formulation have been proposed that includes diclofenac and ranitidine together as enteric coated pellet form which is compressed into tablet formulation. The literature contains numerous reports and experiments that had been studied on the combination preparation of diclofenac and ranitidine together in a single formulation. If this formulation is prepared it can be effectively use in the therapy of NSAID-induced gastrointestinal disorders and will increase patient compliance. The method that has been proposed for pellet manufacture is powder layer technique. Initially two individual enteric coated pellets of ranitidine and diclofenac must be made and then they should be compressed together by direct compression method. The proposed formulations are to be evaluated by performing the dissolution and disintegration analysis. Results: - It is possible to combine diclofenac and ranitidine together as enteric coated pellet form which is then compressed into a tablet. Conclusions: - Compression of coated pellets is a challenging task necessitating the optimization of various formulations and process variables. In this study how two drugs in pellet form can be presented in a more convenient dosage form has been proposed. en_US
dc.language.iso en_US en_US
dc.publisher East West University en_US
dc.relation.ispartofseries ;PHA00036
dc.subject Combination dosage forms, diclofenac, ranitidine, enteric coating, pellet, powder layer technique and direct compression method. en_US
dc.title Prospect of Compressed Pellets of Diclofenac and Rantidine as a Single Tablet Dosage Form en_US
dc.type Thesis en_US


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