Abstract:
Purpose: The purpose of this research work was to compare between the release patterns
of Vento lin and Brodil tablets. Method: Ten tablets of each of Vento lin (from
GlaxoSmith Kline Pharmaceuticals Ltd.) and Brodil (ACI Pharmaceuticals Ltd.) were
collected from the market and were justified by physical parameters like hardness,
thickness, weight variation, friability and dissolution studies. Release kinetics was
measured by using the method inscribed in British Pharmacopoeia. Hardness of the
samples from the market was measured by hardness tester. Thickness of the samples was
measured by Vernier Calipers. Dissolution of the taken samples was investigated using
dissolution tester (RC6, Vanguard Pharmaceuticals, and USA) to evaluate release
kinetics. Result: Mean hardness value of Ventolin and Brodil tablets was found to be
11.64N and 14.72 N, respectively. Mean thickness value of Ventolin and Brodil tablets
was found to be 8.42 mm and 9.77 mm respectively. Percentage difference ofthe weight
variation test ranges from -2.20% to 3.27 % for Ventolin and-2.40% to 3.44% for Brodil.
% friability of Ventolin was found to be 0.17 and of Brodil was found to be - 0.14.
Conclusion: The release pattern of Ventolin tablet meet the requirement to
not
provide desired and optimum therapeutic efficacy, which is ensured by release kinetics of
Brodil.
Description:
This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh.
